Variants of Vitamin K Dependent Coagulation Factors
نویسندگان
چکیده
منابع مشابه
Genetic variants of the vitamin K dependent coagulation system and intraventricular hemorrhage in preterm infants
BACKGROUND Pathogenesis of intraventricular hemorrhage (IVH) in premature infants is multifactorial. Little is known about the impact of genetic variants in the vitamin K-dependent coagulation system on the development of IVH. METHODS Polymorphisms in the genes encoding vitamin K epoxide reductase complex 1 (VKORC1 -1639G>A) and coagulation factor 7 (F7 -323Ins10) were examined prospectively ...
متن کاملStudies on a family with combined functional deficiencies of vitamin K-dependent coagulation factors.
Two siblings with m ild hemorrhagic symptoms had combined functional deficiencies of vitamin K-dependent clotting factors. Prothrombin (0.18-0.20 U/ml) and Stuart factor (Factor X, 0.18-0.20 U/ml) and Stuart factor (Factor X, 0.18-0.20 U/ml) were most severely affected. Antigenic amounts of affected coagulation factors were normal and normal generation of thrombin activity occurred in the patie...
متن کاملVitamin K dependent coagulation proteins in endemic hepatosplenomegaly in Egypt.
AIMS To evaluate the role of bilharzial hepatic fibrosis--whether pure or combined with chronic hepatitis B virus infection--on the functional activity of vitamin K dependent coagulation proteins. METHODS Coagulation screening using prothrombin time (PT), partial thromboplastin time (PTT), and thrombin time (TT) was carried out on 31 patients with endemic Egyptian hepatosplenomegaly and on 14...
متن کاملVitamin K-dependent proteins: functions in blood coagulation and beyond.
Thromb Haemost 2008; 100: 527–529 Vitamin K or vitamin “Koagulation” (German spelling for coagulation) was discovered by the 1943 Nobel Prize winners Henrik Dam and Edward A. Doisy, as a fat soluble substance, the deficiency of which caused bleeding disorders.Vitamin K in its reduced form is required as a cofactor for the γ-glutamyl carboxylase enzyme that catalyses the γ-carboxylation of speci...
متن کاملProcoagulant Vitamin K-dependent Clotting Factors
We have evaluated the contribution of depression of individual procoagulant vitamin K-dependent clotting factors to the ability of warfarin to protect rabbits against tissue factor-induced coagulation. Mean activities of individual procoagulant factors were determined, in assays with rabbit substrates, for a group of rabbits achieving a protective degree of anticoagulation with warfarin. Values...
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ژورنال
عنوان ژورنال: Acta Haematologica
سال: 1979
ISSN: 0001-5792,1421-9662
DOI: 10.1159/000207527